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Despite the fact that they are toxic and carcinogenic, chemotherapy, radiation, and surgery (the “Big 3”) are widely accepted as the standard treatments for cancer. Additional drugs are utilized to stop the growth of cancer cells, treat side effects from the chemo and radiation, and manage pain. Throughout “traditional” cancer treatment, the patient’s body is under attack by the disease and by medical attempts to kill the disease. It is exhausting, dangerous, and the side effects are substantial.
Over the past century, despite their abysmal success rates, the “Big 3” treatments have gradually been accepted by the medical community at large as the “standard of care” for treating cancer. Although they are thought of as “traditional,” they actually are quite new treatments, whereas the treatments that are thought of as “alternative” (such as herbal remedies) have been used for thousands of years. Partly due to this bastardizing of the true meaning of these words and partly due to the vast revenues that they generate, the “Big 3” treatments have become the “norm” – unlike most preventative, alternative, and complementary therapies that do not increase industry profit.
The Science of Immunotherapy
A new treatment has caught the attention of scientists and doctors. Initial results for the patient are incredible. It’s called immunotherapy and the goal is to empower your own immune system to beat cancer. Those interested in the field of immunology recognize the power of the human body. They’d like to put it to work…doing what it does best.
Director of the Cancer Immunology Program, Johns Hopkins University School of Medicine, Dr. Drew Pardoll, PhD, explained, “After years of research in this field, we began to learn that tumors resisted being eliminated by the patient’s immune system by co-opting inhibitory pathways, thus putting the brakes on the immune response. In fact, the tumors could highly upregulate [increase the response of] molecules that would stop a T cell in its tracks and protect the cancer.”
Immunotherapy involves engineering or enhancing the immune cells of the cancer patient to wipe out cancer cells. This therapy is also called adoptive cell transfer (ACT). Initial clinical trial results have been remarkable. Significant improvement to overall patient health, elimination of the cancer cells, and remaining cancer free. Though experts agree that many more studies will need to be done, there is no doubt that the human immune system is up to the challenge if given the right tools.
The Living Drug
Immunotherapy is considered the “living drug.” Its building blocks are T-cells, which are collected from the blood of the patient. These cells are then altered to create “special receptors” referred to as chimeric antigen receptors (CARs). These CARs are a type of protein that enables the T-cells to attack the antigen – the protein found in cancer cells.
These engineered T-cells are cultured in the lab and allowed to grow to billions in number. Then the CAR T-cells are injected into the patient where, if everything goes well, the T-cells will reproduce, seek out cancer cell antigens, and destroy them.
Experimentation on T-cells began in the 1990s when researchers considered it for new cancer treatment. Scientists utilized viral vectors that are deprived of their capacity to produce illness but are still able to join with human DNA to provide the genetic material required for the creation of T-cell receptors.
Second and third generations of CARs have monoclonal antibodies, referred to as “single-chain variable fragments” (scFv), which inhabit the surface of the T-cell membrane and associate with the “stimulatory molecules” within the T-cell. The scFv guides the T-cell toward its target – the antigen. Once the T-cell is linked to the antigen, the stimulatory molecules activate the T-cells to annihilate the cancer cells.
Today, researchers and specialists are finding ways to generate more powerful T-cells that will completely eliminate cancer cells from the patient’s body.
The Benefits of Immunotherapy
Experts think ACT could be the answer to B-cell diseases such as chronic lymphocytic leukemia. Approximately 8-in-10 children who have acute lymphoblastic leukemia (ALL) are treated using intensive chemotherapy. However, if the cancer returns after treatment (which is almost always does), the patients are left with no further options. The ACT is a new option for this group of patients.
Two trials were conducted for the CAR T-cells. Each patient was injected with engineered T-cells to attack the CD19 antigen, which is on the surface of the B cells.
The first trial, referred to as the CHOP trial, was conducted in the University of Pennsylvania. The majority of the patients responded positively to the treatment. Although 3 out of the 17 participants were diagnosed with cancer again, fourteen remained cancer free.
On the second trial conducted at the National Cancer Institute (NCI) by Daniel W. Lee, nine out of fifteen patients responded positively to the treatment. During the trial, two patients received only a small dose of the CAR T-cells compared to the other patients, nevertheless, those patients also reacted to the treatment positively.
Side Effects of Immunotherapy
The ACT causes bothersome side effects referred to as cytokine-release syndrome. Engineered T-cells give off cytokines – chemical messengers that aid the T-cells in completing their mission. Excess cytokines in the bloodstream can cause high fever and low blood pressure.
In the trials conducted for T-cells, some of the patients experienced the syndrome while others only reported mild side effects. Researchers are putting forth their best efforts to improve the ACT process so it can be used as a standard cancer treatment.
If immunotherapy gains ground, as well as the funding and manufacturing ability necessary to administer it, then it will change the face of cancer treatment around the world. We can only hope that it will become more accepted and become oncologists’ first choice to treat their patients – before using toxic chemo drugs, radiation, or surgery.
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Joanne Murray says
Dear Ty – my sister has Stage IV breast cancer – can you please advise where she can try this treatment? My email is firstname.lastname@example.org – thank you!
Hi Joanne, I would suggest taking a look at our experts list. They will be able to either provide treatment or suggest a place to receive treatment for your cancer. Here is the list: https://thetruthaboutcancer.com/experts-info-sheet/
Joanne Murray says
Please advise on how we can get this information to help my sister with Stage IV breast cancer. She goes to Kaiser Permanente and it would be wonderful to see her get this treatment!
The best advice we can give is to consult with one of the doctors we interviewed in our docu-series. We’ve created a page with the experts contact info as it was available to us. Here’s the link to get their info: http://thetruthaboutcancer.com/experts-info-sheet/
Laura will says
Does the truth about cancer apply to someone with carcinoid syndrome
Is there any info in TTAC about Carcinoid Tumor and Carcinoid syndrome that may help?
Hello, i would like to know any information from TTAC about carcinoid tumors.
Teri hansen says
I would like info regarding tx for glio blastoma
Carmel Carty says
Teri Hansen did you get any information with help for GBM – I would be interested too
Advance Australia Fair says
It amazes me that many auto immune diseases have been treated by SUPPRESSING the immune system. With methotrexate arava – cancer drugs and others all to immuno supress. I’ve always though not correct to suppress as we need our immune systems.
So what will happen to those with auto immune systems already suppressed by their disease, and suppression drugs on top – when given this new treatment ? which apparently revs up the immune system. Like driving a car with the foot on the brake the other on the accelerator ?
I have a Cholangiocarcinoma on my liver. Any hope for me?
Advance Australia Fair says
If it is legal in your State please do find out about Herbal Medicinal Cannabis for all cancers and auto immune diseases. Curing/helping many. In conjunction with the radio/chemo – nothing to lose.
Can you use cannabis with immunotherapy?
I have looked at your list of recommended health practitioners and do not see any Homeopathic physicians I am looking for someone in the US who uses mistletoe as a remedy for breast
cancer. Is it legal in the US? I live in OR so would prefer someone in the Pacific NW or CA
I purchased your Asian tour and heard a couple of the doctors who use mistletoe but have
not received my package as yet to look for them 4/22/19
I have not already said that ???
Customer Support says
Hi Judy –
Thank you for your note.
Some expert’s on the list, like Robert Scott Bell, are also trained homeopaths. You could also try doing an online search for local homeopaths in case that’s more helpful for you. 🙂
You could also try getting in touch with the author of this article who is a contributing writer and homeopath – she may be able to steer you in the right direction: https://thetruthaboutcancer.com/homeopathy-and-cancer/. Her website is in the author bio on this article.
If you ordered a physical or combo package your order may still be in transit. The best way to confirm this would be to contact our customer support team with this.
By phone you can reach them at:
They’re available during normal business hours of 9am – 5pm Eastern Standard Time.
Or you can reach out to them anytime via this link:
Hope this helps. 🙂 Please don’t hesitate to let us know if there’s anything else we can help with.
Blessings and love!
I was diagnosed with PRCC in 2018, I am stage 4 metastatic and have had my left kidney removed. I am currently on 40 mg Cabometyx imumunotherapy daily and it is wrecking my digestive system. I was trying to maintain a Mediterranean diet but the fresh fruits and veggies are causing me to have to take Imodium constantly. I don’t even know where to start looking for advise outside of my oncologist/hematologist, which by the way does not even believe in vitamins. I no longer have the energy to exercise or work.